Detalhe da pesquisa
1.
Antithrombotic Effects of Combined PAR (Protease-Activated Receptor)-4 Antagonism and Factor Xa Inhibition.
Arterioscler Thromb Vasc Biol
; 40(11): 2678-2685, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32907366
2.
Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor.
Xenobiotica
; 51(8): 933-948, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34151691
3.
Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.
Bioorg Med Chem Lett
; 30(4): 126949, 2020 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932224
4.
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Bioorg Med Chem Lett
; 29(19): 126604, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31445854
5.
First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects.
Br J Clin Pharmacol
; 84(5): 876-887, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29346838
6.
Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.
Bioorg Med Chem Lett
; 28(6): 987-992, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29501396
7.
Macrocyclic factor XIa inhibitors.
Bioorg Med Chem Lett
; 27(17): 4056-4060, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28780160
8.
Neutral macrocyclic factor VIIa inhibitors.
Bioorg Med Chem Lett
; 27(12): 2650-2654, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28460818
9.
Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.
Bioorg Med Chem Lett
; 27(16): 3833-3839, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28687203
10.
Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.
Bioorg Med Chem Lett
; 26(20): 5051-5057, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27612545
11.
Novel phenylalanine derived diamides as Factor XIa inhibitors.
Bioorg Med Chem Lett
; 26(2): 472-478, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26704266
12.
Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.
Bioorg Med Chem
; 24(10): 2257-72, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27073051
13.
Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors.
Bioorg Med Chem Lett
; 25(10): 2169-73, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25881820
14.
Pyridine and pyridinone-based factor XIa inhibitors.
Bioorg Med Chem Lett
; 25(4): 925-30, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25592713
15.
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
Bioorg Med Chem Lett
; 25(7): 1635-42, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728130
16.
In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa.
J Thromb Thrombolysis
; 40(4): 416-23, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26249722
17.
Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties.
Bioorg Med Chem Lett
; 24(15): 3341-5, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24951330
18.
Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor.
Bioorg Med Chem Lett
; 23(8): 2432-5, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23478148
19.
Nonbenzamidine acylsulfonamide tissue factor-factor VIIa inhibitors.
Bioorg Med Chem Lett
; 23(18): 5244-8, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23845220
20.
Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors.
Bioorg Med Chem Lett
; 23(6): 1604-7, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23416003